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Expected outcome: Modest reductions in cravings and improved energy
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This blockade inhibits the downstream Smad2/3 pathwaywhich otherwise promotes muscle protein degradation and atrophyand instead promotes muscle hypertrophy and differentiation [175]

Supported by the observation of a direct interaction of Epac with SUR1 [73], cAMP may accelerate Cl influx via Epac acting on granular SUR1 (figure 4)
