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Glucagon is a hormone naturally produced by the pancreas that signals the liver to break down and burn stored fats

doi: 10.1038/s41573-018-0008-x

Despite being bed-bound prior to admission, by the end of his fast he regained ambulation (METS level 4) and was able to touch his toes

so what this study suggests is that when hormone therapy is clinically indicated and you combine it with GLP one therapy, that may yield an additive or synergistic effect on weight loss

M., Abd El-Razek, R