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This suggests that these hormones have pleiotropic effects beyond lowering blood glucose levels [9,10,11]

What the research shows on GLP-1 receptor agonists The pharmacology of any legitimate GLP-1 program is driven by the underlying compound class: GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and GIP/GLP-1 dual agonists (tirzepatide)

14,15 Another meta-analysis of 93 clinical trials showed that GLP-1 RAs increased the risk of early-stage DR compared with placebo, with this effect being driven by albiglutide in particular

Available as injectable (Ozempic/Wegovy, weekly) and oral (Rybelsus, daily with fasting restrictions)

GLP-1- based treatments for T2DM, such as GLP-1 receptor agonists, dual and triple agonists that activate GLP-1R, GIPR, and glucagon receptors, and dipeptidyl peptidase-4 (DPP-4) inhibitors have been reviewed here

This mechanism of action explains why these medications often affect digestion as well