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If the skin remains in this stretched state for an extended period as is often the case with obesity those fibers can become damaged and lose their ability to fully retract

thereby, various approaches were used until the albumin binding human GLP-1RAs liraglutide, and subsequently semaglutide were developed

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Some patients may achieve sufficient lifestyle modifications and metabolic improvements to attempt medication discontinuation under medical supervision, while others may require indefinite therapy to maintain benefits

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