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For people on GLP-1 medications, the realistic case for NAD+ includes: better mitochondrial support during caloric restriction, reduced cellular energy depletion in muscle tissue, and based on emerging animal research potential support for the gut environment that produces GLP-1 naturally

The use of specific cAMP analogues and ryanodine or IP 3 receptor antagonists demonstrated that Epac sensitizes the ryanodine receptors and PKA the IP 3 receptors [85,87,91]

Lancet (London, England) 394(10193):121130 Gerstein HC, Lee S-F, Par G, Bethel MA, Colhoun HM, Hoover A, Lakshmanan M, Lin Y, Pirro V, Qian H-R et al (2023) Biomarker changes associated with both dulaglutide and cardiovascular events in the REWIND randomized controlled trial: a nested case-control post hoc analysis

doi: 10.1016/j.clnesp.2022.01.014

GLP-1 medications help with weight loss by making it easier to cut calories, but a smoothie with almost a full days worth of calories might be counterproductive

J Comp Physiol Psychol 84(3):488495 Gutzwiller JP, Drewe J, Gke B, Schmidt H, Rohrer B, Lareida J et al (1999) Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2