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The 5 Clinical Stages opt-out exclusionary screen : end-stage kidney disease, end-stage liver disease (cirrhosis), current suicidal thoughts and prior suicide attempt, active cancer treatment or recent cancer-free history, organ transplant on anti-rejection meds, severe GI conditions (gastroparesis, blockage, IBD), and current alcohol/opioid/substance use disorder

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Yes, some people sleep through early nausea or fatigue when dosing at night

Common side effects include nausea, vomiting, diarrhea, constipation, and stomach discomfort, especially during the early stages or when doses are increased