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At this time, there are no randomized controlled trials evaluating the safety or effectiveness of GLP-1 microdosing protocols in any population

Weight change 2 years after termination of the intensive lifestyle intervention in the look AHEAD study

Since the mean/median duration for each of these studies was 100,000 patients prescribed a GLP-1RA, after propensity matching, there was reduced risk for PDAC during a 5-year observation period for GLP-1RA users compared to six categories of commonly used diabetes medication classes 44

Fast food takes an even harder hit, with spending at limited-service restaurants falling 8.0%

Endocrinology (2015) 156:25567

"Anytime you're manipulating how much someone gets in, it's really hard to out-supplement and out-diet a deficit that's artificially created through an appetite suppressant," he says