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Two studies found GLP-1s were associated with improvement in depressive symptoms and two other studies tied GLP-1s to an improvement in alcohol use disorder among people with obesity

47 In this recent double-blind clinical trial, 47 60 mid-stage PD subjects who were already on dopaminergic replacement therapy were randomized to self-administer exenatide (2 mg Bydureon - slow release exenatide) or a matching placebo once weekly for a duration of 48 weeks

That's a meaningful distinction, and it's the one this whole review is organized around

The answer is nuanced and largely depends on individual health goals, responses to the medication, and the ability to sustain lifestyle modifications

The pen should feel weighted and solid

Compounded medications bypass this process - they are prepared by licensed pharmacies under state and federal compounding regulations, but they do not undergo FDA pre-market review