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Description
The NOS evaluates studies based on three criteria: (1) selection of study groups (representativeness, ascertainment of exposure, and demonstration that the outcome was not present at baseline), (2) comparability of groups (control for confounding factors), and (3) assessment of outcome (adequacy of follow-up and blinding of outcome assessment)

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While these medications commonly cause gastrointestinal side effects such as nausea and constipation, back pain is not listed as a characteristic adverse effect in FDA prescribing information

Clinical Oncology (Royal College of Radiologists), 32 , 591608