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Before starting treatment, discuss contraindications including personal or family history of thyroid cancer, multiple endocrine neoplasia type 2, or severe gastrointestinal disease

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Important: Microdosing has not been evaluated in large randomized clinical trials

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How this compares to injectables (carefully) The authors are explicit: orforglipron does not outperform high-dose injectable tirzepatide , which still leads in average weight loss