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Plainsboro, NJ, Novo Nordisk, 2024 [Google Scholar] 5

1.2 Safety considerations and the limits of the GLP-1 analogy The success of GLP-1 receptor agonists should not obscure legitimate safety considerations associated with chronic peptide therapy

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Based on the significant unmet need in Alzheimers disease as well as a number of indicative data points, we felt we had a responsibility to explore semaglutides potential, despite a low likelihood of success, Martin Holst Lange, chief scientific officer at Novo Nordisk said in a press release

In vivo exploration of neuronal-derived extracellular vesicles represents a promising technique to determine the mechanism of action in centrally-acting drugs [89]