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contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Post-marketing surveillance through the FDA Adverse Event Reporting System (FAERS) and international pharmacovigilance databases continues to monitor for rare or delayed adverse effects

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[11] Renal function should be checked if dehydration is suspected

In the early 1950's, Earl Sutherland and Christian de Duve demonstrated that pancreatic glucagon production was abolished when the function of islet -cells was compromised by treatment with either cobalt or synthalin A but was preserved upon alloxan-induced impairment of the exocrine pancreatic acinar and islet -cells [14,15]

dispose in a sharps container [14]