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1,2,3 Their clinical use is expected to continue to increase, given associated improvement in outcomes with glucose control, cardiovascular disease (CVD), chronic kidney disease (CKD), metabolic dysfunction-associated steatohepatitis (MASH), 4 and obstructive sleep apnea (OSA)

5.It promotes fat oxidation, encouraging the body to use stored fat for energy

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A recent phase II study using OCA plus atorvastatin therapy initiated at 4 weeks to ameliorate the elevation of LDL cholesterol from OCA (CONTROL) in 84 biopsies confirmed that NASH patients showed no significant elevation in LDL cholesterol at 8 weeks (27)