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As of 2021, the International Diabetes Federation (IDF) estimates that approximately 537 million adults have diabetes globally, and this number is forecast to rise to 783 million by 2045

Mechanistic studies further support the rationale for combination therapy

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They help control blood sugar, support weight loss, and can lower the risk of heart and kidney problems and improve liver disease for some people

Clinicians might consider preferring GLP-1 receptor agonists over other diabetes treatments, such as insulin, for patients at high risk of obesity-associated cancers. Wang and colleagues conducted a retrospective cohort study of deidentified electronic health records on the TriNetX platform

13 Our team conducted a meta-analysis of all GLP-1 RA randomized clinical trials (RCTs) and found that albiglutide, an FDA-approved medication that is no longer available in the United States, was associated with an increased risk of DR