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Bellwether trials in mid-2026 will likely accelerate settlement discussions

FDA-approved candidates include adults with BMI 30 kg/m or BMI 27 kg/m with weight-related comorbidities such as hypertension, dyslipidemia, or cardiovascular disease

On average, patients in the RaeRx program lose 15-20% of their body weight

Currently, there is only two classes of drugs approved for the treatment of AD: N-methyl D -aspartate (NMDA) antagonist (memantine), and cholinesterase inhibitors (tacrine, Donepezil, galantamine, rivastigmine)

Glycemic control appears to be more effective when both receptors are activated [99, 100]

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