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As a result, the increased secondary BAs can activate TGR5, which increases L-cells and GLP-1 secretion by inhibiting the RhoA/ROCK pathway and inducing YAP activation [157, 203]

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When stored correctly in a freezer (-20C or colder) and kept away from moisture and light, the powder can retain its full potency for several years

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Biologic Rationale: How GLP1 Might Affect Bone The skeleton responds to a wide array of hormonal and metabolic signals
