glp-1 receptor agonist nausea diarrhea management Agonists in Gastrointestinal Practices: Enhancing Both Procedural and Patient-Related Outcomes | SN Comprehensive Clinical Medicine GI Adverse Effects of Glucagon-Like
Description
Lillys oral GLP-1, orforglipron, demonstrated statistically significant efficacy results and a safety profile consistent with injectable GLP-1 medicines in successful Phase 3 trial | Eli Lilly and Company [Internet]

Dulaglutide also has shown kidney benefits (slower progression of albuminuria) in that trial
In our large, nationwide cohort study with a median follow-up of 8 years, we observed no increase in pancreatic cancer risk with GLP-1 RA use compared to other antidiabetic drug users

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CBC also noted that Canada is the only country where Novo Nordisk allowed the patent for its semaglutide drugs to expire, with regulatory exclusivity ending January 4 [Source: cbc.ca/news/health/ozempic-glp1-health-canada-generic-9.7034498]
In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials