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The high pressure equipment used to induce high shear force requires to disrupt the cell structure

Finally, as a more objective measure of activity, we tracked voluntary physical activity in a set-up in which the mice were continuously housed in cages with free access to running wheels

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Where GLP-1 agonists often produce a sensation of fullness and food aversion (sometimes to the point of gastrointestinal discomfort ), amylin-based satiety typically manifests as a more gentle reduction in hunger drive