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Supplementation with indole-3-propionic acid (IPA), a metabolite produced by GM from tryptophan, reduces the F/B ratio, and also reduces diastolic dysfunction and HFpEF-induced diastolic dysfunction and HFpEF-induced cardiac hypertrophy in the heart by inhibiting the expression of pro-inflammatory cytokines, such as TNF-, IL-6, and IL-1 in the heart of mice [110]

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In some embodiments, the CpG-Ab immunoconjugate specifically binds to a tumor-associated antigen of the cancer being treated by the present method

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The relative contribution of these processes is quite variable, but it appears that the vasculopathy may be more prominent in older fetuses

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