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Activation of D 2 receptors has been shown to blunt cocaine sensitization (Beyer and Steketee, 2002), while D 2 antagonists or receptor knockout generally does not greatly alter acute locomotor activation, sensitization, or CPP (Spyraki et al., 1982

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Until then, the focus remains on careful, methodical, and responsible investigation

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The research on BPC-157 encompasses investigations into its mechanisms of action, efficacy, safety, and potential therapeutic applications