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Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (, )

In pre-clinical research, it is primarily studied for its effects on gastrointestinal healing, tendon and ligament repair, vascular growth (angiogenesis), and potential neuroprotective properties

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In this study, we showed intense elastin staining compared to intact tendons

Taking that into consideration, the FDA insisted users and doctors weigh the known benefits against the potential risks while deciding to use such a prescription drug