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Outside of the lung, TNF- plays a major role in the systemic effects of COPD, such as endothelial dysfunction and muscle wasting associated with elevated systemic TNF- levels in COPD patients

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[18] To avoid this, the cell tightly regulates these pathways through three main mechanisms: allosteric regulation covalent modification (e.g., phosphorylation and dephosphorylation)

[DOI] [PubMed] [Google Scholar] 216.Yanaka A., Fahey J.W., Fukumoto A., Nakayama M., Inoue S., Zhang S.H., Tauchi M., Suzuki H., Hyodo I., Yamamoto M