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Here, we demonstrated that an alternative dosing approach via oral gavage with a well-tolerated, lower dose of cuprizone resulted in significant differences in C57BL/6NTac (Taconic) over C57BL/6J (Jax) mice

For a given absolute rate of heat production, the resultant change in deep body temperature is inversely related to mass (the bodys heat sink) and body composition (the bodys specific heat capacity), although the latter becomes apparent only when comparing individuals of vastly different adiposity levels

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