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The ice crystal formation physically damages the peptide structure, and this damage does not reverse when the solution thaws
Metabolic actions of growth hormone in man
Correlation of Tc-99 m ethyl cysteinate dimer single-photon emission computed tomography and clinical presentations in patients with low cobalamin status
They measured the full B12 body count of four people and found it to be 780 to 1,350 g of B12 with a daily loss of 0.12% for a maximum loss of 1.6 g per day or 11.2 g per week
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