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[DOI] [PubMed] [Google Scholar] 173.Aggarwal G, May-Zhang LS, Yermalitsky V, Dikalov S, Voynov MA, Amarnath V, Kon V, Linton MF, Vickers KC and Davies SS

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The discovery of Siglec-8's effect was first made by cross-linking Siglec-8 with antibodies, which caused rapid eosinophil apoptosis in vitro (181)

51, 74, 75, 76, 77, 78 The molecular mechanisms that underlie the cytotoxic potential of cytoplasmic CDDP are poorly understood, yet may involve: (i) the accumulation of reactive oxygen species (ROS) and nitric oxide (NO), which not only exacerbate CDDP genotoxicity but also exert direct cytotoxic effects by favoring the opening of the so-called permeability transition pore complex (PTPC)