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The competitive IRAP inhibitor 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity

Functional isometric exercises and eccentric physical therapy is the best in this case

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The optimal concentration window stimulates maximum growth, while higher concentrations can trigger inhibitory feedback

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