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Furthermore, the diversity of gut microbiota taxa and the abundance of bacterial gene families are associated with the inhibitory effect of drugs on DHFR [121]

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7 Applications of host-directed therapies in treating intracellular pathogens The poor bioavailability of antibiotics in infected tissues often necessitates higher dosing and prolonged treatment regimens, particularly when combating drug-resistant infections

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Long-term ecological monitoring is necessary to study the cumulative effects and long-term impact of SSRIs and their metabolites in different ecosystems and their potential reproductive system toxicity

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