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The side effect profiles also differ , and some researchers switch between the two based on response and tolerance

Unlike classical mediators such as TNF-, the activity of RvE1 is tightly confined within an immune-moderate response range, preventing excessive inflammatory damage

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However, Gepon did not significantly affect the levels of these anti-inflammatory mediators, suggesting its primary mechanism was suppression of pro-inflammatory signaling rather than enhancement of anti-inflammatory pathways

Zhao L, Zhang S, Anik X, Tan W, Pang D, Ouyang H