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Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

If these baroreceptors are damaged by oxidative stress or demyelination, they cannot accurately signal the body to constrict blood vessels when you stand up, leading to blood pooling in the lower extremities and subsequent tachycardia

This viral persistence is thought to drive ongoing immune activation, prompting the immune system to continuously mount responses against the viral antigens it keeps detecting

doi: 10.1038/sj.ijo.0803446

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