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While the mitochondrion is the primary source of ROS in most cells [16], mature RBCs lack mitochondria, and, instead, the oxygen carrier protein, Hb, is the major source of ROS, produced as a result of autoxidation

W., Domanska, A., Seppala, A

[PubMed: 21224288] 103

Thus, one emerging hypothesis is that that increasing copper can react with reductive GSH, which might result in the decreased FDX1 and increased lipid peroxidation, further promoting oxidative damage [173175]

Trichomed Hair Clinic Berlin, Germany, poster presented at the 15th EHRS annual meeting, July 69, 2011, in Jerusalem, Israel

Zhu W, Cromie MM, Cai Q, Lv T, Singh K, Gao W