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on the other hand, excessive NET formation releases histones and proteases that damage alveolar epithelial and endothelial cells and exacerbate airway inflammation and fibrosis by activating inflammasomes and promoting cytokine release, ultimately leading to lung tissue damage (144)
10.4081/jbr.2018.7203 68 MorasM.LefevreS
Free radical compounds can cause oxidative stress, thereby decreasing endogenous antioxidants such as reduced glutathione (GSH)
All these circumstances decrease the amount of NO and cause the loss of endothelial function
Methylation can occur in both histones and DNA
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