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The liver is an organ with active oxidative metabolism in the body
doi: 10.1186/s40168-020-00845-6 183 XinG
Functional magnetic resonance imaging (fMRI) evidence in healthy humans has confirmed that tcVNS activates the ipsilateral NTS and bilateral insula, thalamus, anterior cingulate cortex (ACC), and dorsal lateral prefrontal cortex (Frangos and Komisaruk 2017)
Bjrklund G, Meguid NA, El-Bana MA, Tinkov AA, Saad K, Dadar M, Hemimi M, Skalny AV, Hosnedlov B, Kizek R, Osredkar J, Urbina MA, Fabjan T, Elhoufey A, Kauna-Czapliska J, Gtarek P, Chirumbolo S (2020b) Oxidative stress in autism spectrum disorder
"BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis"
209 They found laser irradiation immediately caused BBB breakdown which looked to be associated with structural damaged regions of brain microvessels
