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Long-term safety data from the STEP 5 trial demonstrates that participants who continued therapy for two years experienced most of their side effects during the first 6 months, with markedly fewer events in the second year
30 , e13348 (2018)

Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: A double-blind, placebo-controlled cross-over clinical trial
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders

Even low-grade discomfort that doesnt fully wake you can prevent deep sleep stages, leaving you feeling unrested despite spending adequate time in bed
