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Elevated oxidative stress and subsequent mitochondrial dysfunction are associated with biological aging

doi: 10.1038/sj.bjc.6603487 50 MatboliMEl-NakeepSHossamNHabiebAAzazyAEEbrahimAEet al

Arfsten DP, Johnson EW, Thitoff AR, Jung AE, Wilfong ER, Lohrke SM, et al

Honest assessment of priorities helps ensure resources are allocated in ways that maximize health outcomes and personal satisfaction
This concern mainly applies to people taking high doses of biotin, typically in the range of many milligrams per day (far above the normal dietary amount)

GSH can modulate the activity of various redox-sensitive signaling pathways, including the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which regulates the expression of antioxidant and detoxification genes, and the mitogen-activated protein kinase (MAPK) pathway, which regulates cell proliferation, differentiation, and apoptosis
