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Int J Cancer

10.1016/s0031-9422(02)00116-4 55 DobrydnevA

doi: 10.1021/jf102807t 18 CentenoD

Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase

Interestingly, mitochondria and peroxisomes share key components of their division machinery 165 , raising the possibility for such a currently hypothetical mechanism

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