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There are a number of inherent difficulties in diagnostic procedures for nephropathy, which include the absence of standard diagnostic criteria and the inability to relate exposure to a given agent and the observed effect

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In individuals with confirmed B12 deficiency, B12 supplementation is required, with the choice of formulation, duration and dosage guided by the underlying cause and severity of the deficiency and patient preference

The SFNSL data obtained at the end of dosing at wk 4 are expressed as a cumulative proportion of the responders plot in Figure 3

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