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Due to unavailability of appropriate, non-infectious human liver tissue, NMtBu as well as further NAs could not be tested in PCLiS

Their reliability in research depends on minimizing heterogeneity including any introduced during culturing, and where altered FBS composition can reduce reproducibility (Wu et al., 2021)

The persistence of exercise-induced effects, the optimal timing for initiating exercise, and the intensity of the intervention require further investigation (Ryan and Kelly, 2016)

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[58] in their work reported that drugs modulating 2 and 3 subunits of GABA A receptors and sparing 1 subunit would be more antinociceptive for relieving chronic pain