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2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter

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Unlike intramuscular delivery, theres essentially no risk of nerve injury

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Corticotropin-releasing factor (CRF): Mechanism to elevate mean arterial pressure and heart rate

Os benefcios mais bem documentados nos estudos pr-clnicos incluem: acelerao da cicatrizao de tendes e ligamentos (com melhora das propriedades biomecnicas), proteo da mucosa gstrica contra AINEs e lcool (reduo de 78% da superfcie ulcerosa em modelos animais), estimulao da angiognese via VEGF, e efeitos neuroprotetores em modelos de leso cerebral