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The limitations of clinical endpoints further compound the problem
Trends Immunol (2006) 27:47.10.1016/j.it.2005.11.002 49 RathmellJCElstromRLCinalliRMThompsonCB
A global RNA splicing signature in patient fibroblasts We next tested whether different FUS/TLS mutations conferred a common set of splicing changes when expressed from the normal human FUS/TLS locus
486 However, in a follow up multi-centre phase 2 trial in participants with early Parkinsons disease, deferiprone was associated with worse scores in measures of parkinsonism than those with placebo over a period of 36 weeks
Such disturbances have been described in ASD brain tissue and support the relevance of methyl-donor pathways in ASD biology [32,33,34]
10.1016/j.biopha.2022.112658 9 Al MamunA.HashimotoM.KatakuraM.HossainS.ShidoO
