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PubMed,

Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle Study

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Decreased expression of GPx1, due to the cellular accumulation of S-adenosylhomocysteine, was found to promote oxidative stress, as hydrogen peroxide release from cells (measured by Amplex Red) as well as intracellular hydrogen peroxide production (measured by Hyper, a live-cell hydrogen peroxide probe) were enhanced by exposure of endothelial cells to increased amounts of S-adenosylhomocysteine

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It is divided into two main types: hemorrhagic stroke and ischemic stroke, with ischemic stroke being more prevalent[50]