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CMU J Nat Sci (2009) 8.2 219

Science 317, 10831086

In conclusion, hemeHPX, which regulates cell iron homeostasis and proliferation/cell growth, is taken up by clathrin-mediated endocytosis and raises intracellular ferrous iron safely for the IRE/IRP system of translational regulation

Treatment of breast cancer cells with mitochondrion- targeted deferoxamine (mitoDFO) impaired ironsulfur [Fe-S] cluster/heme biogenesis and inhibited mitochondrial respiration, inducing mitophagy and promoting ferroptosis [111]

(2008) Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Zheng J, Ahmad AA, Yang Y, et al
