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Quercetin is fat-soluble, so it is often better tolerated and absorbed when taken with a meal that contains healthy fats, like avocado or olive oil

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doi:10.1016/j.jasms.2009.02.011 Piepponen TP, Skujins A (2001) Rapid and sensitive step gradient assays of glutamate, glycine, taurine and gamma-aminobutyric acid by high-performance liquid chromatography-fluorescence detection with o-phthalaldehyde-mercaptoethanol derivatization with an emphasis on microdialysis samples