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In singlecell organisms, such as Escherichia coli bacteria, these principles are implemented by intracellular signaling pathways to support a biasedrandom walk chemotaxis strategy (Block et al , 1983

Transitioning from egg to embryo: triggers and mechanisms of egg activation

These observations suggest that, in wild-type cultures, physiologically relevant amounts of TisB protein accumulate only after long periods of SOS induction, which is congruent with strong post-transcriptional repression of tisB mRNA by its 5 UTR structure and antitoxin IstR-1 (Vogel et al., 2004

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Non-cleavable linkers can potentially provide a greater therapeutic window compared to cleavable linkers, due to the fact that the payload derivative from non-cleavable ADCs can kill the target cells [43,46]

J Experimental Basic Med Sci