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In conclusion, the collective studies carried out in recent years on the characterization of IDH-mutant tumors highlight an admirable paradigm of the virtuosic transfer from basic research (with improvements in our understanding of the physio-pathological role played by IDH mutations in the development of some tumors) to clinical studies (with the development of selective, potent and clinically-active IDH inhibitors)

Trends in Endocrinology and Metabolism (2017) 7

Acknowledgements This research was supported by the project STIM-REI, Contract Number: KK.01.1.1.01.0003, funded by the European Union through the European Regional Development Fundthe Operational Programme Competitiveness and Cohesion 20142020 (KK.01.1.1.01)

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In addition to this mechanism, reduced glucose uptake could likely also reflect decreased expression of glucose transporters, as DHT was shown to lower GLUT1 and GLUT4 levels in white adipose tissue (WAT) from female mice [101]

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