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have found that during MMP, p62 may induce autophagy by binding to the ubiquitinated VDAC1 protein localized on the OMM [278]

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Out of the major risk factors, which include diabetes, smoking, and dyslipidemia, hypertension is by far the most prevalent trigger for CVDs, and its comorbidity with other risk factors is even more puissant (Yang et al., 2011

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