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Loss of primary pyruvate dehydrogenase complex enzymatic function may occur from loss of mRNA expression, subunit instability, or loss or reduction of functional activity of various primary pyruvate dehydrogenase complex-associated gene products (Table 2), which could, in part, be due to partial or complete deletion of the specific gene

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(2024, June 14)

Furthermore, hepatic first-pass metabolism may not be a major component of the overall clearance of glucosamine since i.p