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Male, but not female, rats with a history of AIE showed significantly increased dextran permeability in the nucleus accumbens (NAc), cingulate prefrontal cortex (cPFC), and amygdala (AMG)

Conclusion BBB-targeted polypeptide nanoparticles coupled to therapeutic molecules were effectively taken up by brain organoids or showing a BBB protective effect indicating potential applications in nervous system pathologies
Synergistic rather than merely additive

PMID: 30915550 Seiwerth S, et al

PMID: 40499810 SLAS Discov 2020 Sep;25(8):895-905
